Ben Glocker is the guest editor together with Nikos Paragios (Ecole Centrale Paris) and Ramin Zabih (Cornell NYC Tech / Weill Cornell Radiology) of a special issue on Discrete Graphical Models in Biomedical Image Analysis, which will be published in Vol. 27 of Medical Image Analysis in January 2016. The special issue has nine excellent articles covering a wide range of applications, including the work by Martin Rajchl on Hierarchical max-flow segmentation framework for multi-atlas segmentation with Kohonen self-organizing map based Gaussian mixture modeling.